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Mehr Details· Schrödinger is the scientific leader in developing state-of-the-art chemical simulation software for use in pharmaceutical, biotechnology, and materials research. Our physics-based computational platform leverages a deep understanding of physics, chemistry, and
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Mehr Details· AstraZeneca Plc (NASDAQ: AZN) struck a deal with a startup for a self-amplifying RNA (saRNA) therapeutics platform developed at Imperial College London. Under the deal, VaxEquity could receive up ...
Mehr DetailsTo overcome pandemics, such as COVID-19, vaccines are urgently needed at very high volumes. Here we assess the techno-economic feasibility of producing RNA vaccines for the demand associated with a global vaccination campaign. Production process
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Mehr DetailsAbstract. Self-amplifying RNA (saRNA) is a next-generation vaccine platform, but like all nucleic acids, requires a delivery vehicle to promote cellular uptake and protect the saRNA from degradation. To date, delivery platforms for saRNA have included lipid nanoparticles (LNP), polyplexes and cationic nanoemulsions; of these LNP are the most ...
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Mehr DetailsAt Chimeron Bio, we are committed to the development of our ChaESAR particle and RNA technology to bring forward innovative therapeutics across indications. Our current pipeline includes programs in oncology, liver and vaccines that are novel, highly differentiated and that stand to improve the lives of patients worldwide.
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Mehr DetailsDevelopment of GalNAc-conjugated saRNA targeting HNF4A for treatment of metabolic disease Jon Voutila 1, Karin Purdie 1, Alexandre Debacker 1, Vikash Reebye 1,2, Kai-Wen Huang 3, Matthew Catley 1, David Blakey 1, Robert Habib 1, Pal Saetrom 4 …
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Mehr Details· Currently, the world has unequal access to vaccines, meaning that new and powerful variants will continue to mutate until all countries are majority-double dosed. In this study, they looked at the impact of a different vaccine tech in 192 people, aged between 18-45. They found that 87% of the group created a strong antibody response when given ...
Mehr Details· saRNA synthesis saRNA encoding the nonstructural proteins of the Venezuelan equine encephalitis virus (VEEV) and either fLuc [] or HIV-1 Env gp140 [] was synthesized using in vitro transcription ...
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